Research Areas
Research and Development of Bioactive Components in Traditional Chinese Medicine
Education
1983, Department of Traditional Chinese Medicine, Beijing College of Traditional Chinese Medicine; Major in Traditional Chinese Materia Medica
In the same year, was assigned to the Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine.
Work Experience
1989 – Assistant Researcher
1995 – Associate Researcher;
1999 Researcher;
1984–1985: Visiting Researcher, Institute of Kampo Medicine, Shizuoka University of Pharmacy, Japan;
1995–1998: Collaborative research with Central Research Institute, Mura Co., Ltd. (Japan).
Academic Thought
1. Research on Active Components of Traditional Chinese Medicine and New Drug Development
AtOver 30 years of research in traditional Chinese medicine (TCM), we have extracted, isolated, and identified active compounds from more than ten herbal medicines, including Ardisia crenata, jasmine roots, lotus plumules, Cynanchum paniculatum, Spatholobus suberectus, Aconitum carmichaelii, Sophora japonica, Salvia miltiorrhiza, Andrographis paniculata, and toad skin. These efforts revealed the active constituents underlying TCM efficacy, laying a solid foundation for the development of TCM active ingredients and the establishment of quality standards. In particular, our work on Rehmannia glutinosa led to the isolation of compounds from its aerial stems and leaves, identification of bioactive components, and comprehensive utilization of Rehmannia leaves—resulting in their approval as a national-level new drug. Additionally, we drafted "A Long- and Medium-Term Development Plan for China's TCM Industry," playing a pivotal role in shaping major policy decisions for the industry's advancement.
2Research on Evaluating the Correlation Between Active Ingredients and Therapeutic Effects of Traditional Chinese Medicine
Based on the classic ancient formula for clearing heat and activating blood (Huanglian Jiedu Decoction) as well as commonly used blood-activating and stasis-resolving herb pairs (Salvia miltiorrhiza- Chuanxiong) and herbs that move qi and break blood, such as EzhuAs the research subject, this study focuses on the core effects of clearing heat, activating blood, regulating qi, and breaking stasis. Through integrated scientific research spanning chemistry, pharmacology, and biology, it investigates the functional correlations among clusters of traditional Chinese medicine (TCM) ingredients. The aim is to elucidate the relationship between these effective ingredient clusters and the specified blood-activating formulas (including those for clearing heat).、the efficacy correlations among blood stasis resolution, qi regulation, and blood breaking; establish a technology to evaluate efficacy correlations among effective component groups; provide a foundation for scientifically interpreting the holistic regulation theory of Traditional Chinese Medicine (TCM); and offer methodological and technical support for scientifically evaluating TCM formula efficacy.
Part-time Social Job
Member of the Beijing Dongcheng District Committee of the Chinese People's Political Consultative Conference
Taishan Scholar Pharmacy Distinguished Expert
China Association for Promotion of Traditional Chinese Medicine Research Chemical Committee of Traditional Chinese Medicine Chairperson
China Association of Chinese Medicine TCM Processing Professional Committee Chairperson
National Natural Science Foundation of China Project Review Expert
National Development and Reform Commission Drug Price Review Expert
Executive Director of the China Association for Promoting Traditional Chinese Medicine Research
Chinese Journal of Pharmacoeconomics Editorial Board Member
China Journal of Pharmaceutical Economics and Management Editorial Board Member
Chinese Journal of Traditional Chinese Medicine Editorial Board Member
Modern Drugs and Clinical Practice Editorial Board Member
Chinese Journal of Experimental Traditional Medical Formulae Editorial Board Member
Patent
1. Total triterpenoid saponins from Ardisia crenata and related species, and preparation method thereof CN99105451.2
2. Rehmannia leaf extract, its preparation method and use, and pharmaceutical preparations comprising said extract CN200610021877.4
3. A drug for treating gout and a preparation method thereof CN200710175700.4
4. A health food for regulating irregular menstruation and its preparation method CN200710175699.5
5. A health food for improving women's immune function and enhancing beauty CN200710175698.0
6. Method for extracting nutrients from jujubes and iron stick yams CN200810114763.3
7. Method for detecting total glycosides from Rehmannia leaves in capsule form CN201010251405.4
8. Detection and Identification of Two Component Groups in Toad Skin Extracts CN201410269270.2
9. Antitumor active composition from toad skin, preparation method and use thereof CN201510391023.4
10. Artificial cultivation, processing, detection, and applications of Cordyceps militaris from Tussah silkworm pupae as a Chinese medicinal herb CN201510132763.6
11. A Cedar-Juniper Composition and Its Detection Method CN201310064852.2
12. Gardenia extract for treating hypercholanemia, its preparation and application CN201811378343.6
13. A processing device for reducing toxicity and increasing the purity of active ingredients in Chinese herbal medicine CN202220418675.8
14. A method for distinguishing 25 heads from fewer than 80 heads of Panax notoginseng based on untargeted metabolomics CN202110667454.4
15. Method for preparing Qingfei Paidu granules CN202110771862.4
Monograph
1. Monograph on Rehmannia, edited by Bian Baolin 2010, China Ancient Books Publishing House
2. "Zao Lun" Edited by Li Zhimin and Bian Baolin, 2010, China Social Publishing House
3. "Monograph on Yam", edited by Bian Baolin and Chang Hong, 2010, China Ancient Books Publishing House
4. "A Monograph of Rehmanniae Radix", edited by Bian Baolin, 2012, China Ancient Books Publishing House
5. "Experimental Research Techniques and Equipment for Traditional Chinese Medicine," edited by Bian Baolin, Cao Jun, and Hao Qingxiu. 2012, Science Press
6. "Special Treatise on Achyranthes" Edited by Bian Baolin and Chang Hong 2013, China Ancient Books Publishing House
7. Editorial Board Member of "Research on Processing Aids for Traditional Chinese Medicine" 2013, Xueyuan Publishing House
8. Deputy Editor-in-Chief, "Guidelines for the Development of Classic Prescriptions," 2020, Science Press
9. Editorial Board of "New Chinese Materia Medica" 2020 China Medical Science and Technology Press
Results
Beijing Science and Technology Award:2 items
1. Research on Active Ingredients of Rehmannia Leaves for Treating Glomerulonephritis Third Prize 2004 Year
2. Study on the Anti-Tumor Activity of Pentacyclic Triterpenoid Saponins from Ardisia crenata Third Prize 2006Year
China Association of Chinese Medicine Science and Technology Award:2 items
3. Key Safety Issues in the Development of Traditional Chinese Medicine (TCM) Injections Second Prize 2012Year
4. Study on Active Ingredients in Rehmannia glutinosa Leaves for Treating Chronic Glomerulonephritis Third Prize 2004Year
Science and Technology Progress Award of the China Association for Traditional Chinese Medicine Research Promotion3 items
5.Mechanisms of Anti-Hepatocellular Carcinoma Activity by Active Components of Huachansu Injection and Its Clinical Application First Prize 2015Year
6Clinical Biomarker Study of Huanglian Jiedu Wan, a New Syndrome-Based Drug for Treating "Excess Heat and Fire" Second Prize 2022Year
7Key Technologies and Applications for Quality Improvement of Huachansu Series Formulations Derived from Toxic Animal Drugs Third Prize 2022Year
China Academy of Chinese Medical Sciences Level Award:6 items
8. Research on Active Components of Chinese Medicine Huaansu First Prize 2019Year
9. Study of Active Ingredients in Rehmannia Leaves for Treating Glomerulonephritis Second Prize 2003Year
10. Chinese herbal medicines (e.g., rhubarb, hawthorn, salvia miltiorrhiza)Quality standard research for 13 types Second Prize 2004Year
11. Basic Research on Safety Evaluation and Rational Drug Use of Senecio Scandens and Qianbai Biyan Tablets Second Prize 2009Year
12. Research on Anti-tumor Active Components of Ardisia crenata Second Prize 2002Year
13. Rehmannia, Notoginseng, and othersResearch on Technical Standards for Safety Limits of Heavy Metals and Pesticide Residues in 8 Types of Traditional Chinese MedicinesThird Prize2005Year
Certificate of Reference Standard for Traditional Chinese Medicine Chemistry：1 items
14. Received the "Rutin Reference Material Certificate" for Chinese herbal chemistry standards. 2007Year
Anhui ProvinceScience and Technology Award:
15. Establishment and Application of a Systematic Research Model for Key Technologies of Huachansu, a Traditional Chinese Medicine Based on Clinical Efficacy - Second Prize 2020
CNCountryEthnicityPharmaceutical Association Science and Technology Award:
16. Promoting the commercialization of toad farming projects in Liangshan Yi Autonomous Prefecture, Sichuan Province, through research on the active compounds of traditional Chinese medicine raw materials (whole toads, toad venom, and toad skin). First Prize 2021Year
Chinese Society of Integrated Traditional Chinese and Western Medicine：
17. Study on the Mechanism of Action of Total Glycosides from Rehmannia Leaf in Treating Chronic Glomerulonephritis Third Prize 2022Year